Heat Biologics, Inc.

801 Capitola Drive, Suite 12
Durham, North Carolina 27713

October 18, 2017

VIA EDGAR

Securities and Exchange Commission

Division of Corporation Finance
100 F Street, NE
Washington, D.C. 20549
Attention:  Chris Edwards

Re:

Heat Biologics, Inc.

Registration Statement on Form S-1

File No. 333-220470                                                        

Dear Mr. Edwards:

Heat Biologics, Inc. (the “Company”) hereby requests that the effective date of the Company’s Registration Statement on Form S-1 (File No. 333-220470) be accelerated by the U.S. Securities and Exchange Commission to 4:00 pm, New York City Time, on October 19, 2017, or as soon as reasonably practicable thereafter.

The Company hereby authorizes Leslie Marlow and Patrick Egan of Gracin & Marlow, LLP to orally modify or withdraw this request for acceleration. Please contact Ms. Marlow at (516) 496-2223 or (212) 907-6457, or Mr. Egan at (914) 557-5574 with any questions you may have concerning this request, and please notify either of them when this request for acceleration has been granted.