Heat Biologics, Inc.

801 Capitola Drive, Suite 12
Durham, North Carolina 27713

May 2, 2018

VIA EDGAR

U.S. Securities and Exchange Commission

Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
Attention:  Dorrie Yale

Re:

Heat Biologics, Inc.

Registration Statement on Form S-1

File No. 333-224039                                                        

Dear Ms. Yale:

Heat Biologics, Inc. (the “Company”) hereby requests that the effective date of the Company’s Registration Statement on Form S-1, as amended (File No. 333-224039), be accelerated by the U.S. Securities and Exchange Commission to Wednesday, May 2, 2018 at 4:15 pm, New York City Time, or as soon as reasonably practicable thereafter.

The Company hereby authorizes Leslie Marlow and/or Patrick Egan of Gracin & Marlow, LLP to orally modify or withdraw this request for acceleration. Please contact Ms. Marlow at (516) 496-2223 or (212) 907-6457, or Mr. Egan at (914) 557-5574 with any questions you may have concerning this request, and please notify either of them when this request for acceleration has been granted.