EXHIBIT 23.1

Consent of Independent Registered Public Accounting Firm

Heat Biologics, Inc.

Durham, North Carolina

We hereby consent to the incorporation by reference in the Registration Statements on Form S­3 (No. 333-199274) and Form S-8 (No. 333-193453 and 333-196763) of Heat Biologics, Inc. of our report dated March 27, 2015, relating to the consolidated financial statements, which appears in this Form 10-K.

/s/ BDO USA, LLP

BDO USA, LLP

Raleigh, North Carolina

March 27, 2015