Form: 10-K

Annual report pursuant to Section 13 and 15(d)

April 26, 2024

EXHIBIT 21.1

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Scorpius Holdings, Inc. Subsidiaries

Name of Subsidiary

Jurisdiction

Heat Biologics I, Inc

Delaware

Heat Biologics III, Inc.

Delaware

Heat Biologics IV, Inc.

Delaware

Heat Biologics GmbH

Germany

Heat Biologics Australia Pty LTD

Australia

Zolovax, Inc.

Delaware

Pelican Therapeutics, Inc.1

Delaware

Skunkworx Labs, Inc.3

Delaware

Scorpius Biomanufacturing, Inc. 3

Delaware

Abacus Biotech, Inc.3

Delaware

Blackhawk Bio, Inc.3

Delaware

1Formerly Heat Biologics II, Inc. believed to be formed in 2008 and divested in 2012. Refer to 2020 10-K.

Jeffrey Wolf was issued an option to purchase up to 5% of the outstanding shares of Scorpius Biomanufacturing, Inc. and William Ostrander was issued an option to purchase up to 1% of the outstanding shares of Scorpius Biomanufacturing, Inc., both options were exercised in full.

3Each of these entities are parties to a subsidiary incentive plan pursuant to which options have been issued.